Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice.
J Clin Invest. 2012 May 1; 122(5):1758-63
Michael Fessler
29 May 2012
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New Finding
This landmark paper advances our understanding of the complex inter-organ crosstalk that orchestrates the integrated host defense response of animals to environmental insult. Specifically, the authors define, for the first time, a clear and essential role for the acute phase response (APR) of the liver in the integrated in vivo...
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