Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice.
J Clin Invest. 2012 May 1; 122(5):1758-63
Quinton LJ, Blahna MT, Jones MR, Allen E, ..., Schmid RM, Pelton SI, Spira A, Mizgerd JP. Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Hilliard KL, Zhang X, Sabharwal V, Algül H, Akira S, Schmid RM, Pelton SI, Spira A, Mizgerd JP. J Clin Invest. 2012 May 1; 122(5):1758-63
This landmark paper advances our understanding of the complex inter-organ crosstalk that orchestrates the integrated host defense response of animals to environmental insult. Specifically, the authors define, for the first time, a clear and essential role for the acute phase response (APR) of the liver in the integrated in vivo...
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