Synergistic interactions of SQ109, a new ethylene diamine, with front-line antitubercular drugs in vitro.
J Antimicrob Chemother. 2006 Aug; 58(2):332-7
Chen P, Gearhart J, Protopopova M, Einck L, Nacy CA. J Antimicrob Chemother. 2006 Aug; 58(2):332-7
This study shows that the tuberculosis drug SQ109 is synergistic with isoniazid, rifampicin, and TMC207 and has activity against ethambutol-resistant strains in vitro. SQ109 has a dual mechanism of action: it blocks cell wall synthesis and prevents the efflux of companion drugs from macrophages.
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