Environmental control of the cell cycle in Drosophila: nutrition activates mitotic and endoreplicative cells by distinct mechanisms.
Development. 1998 Jun; 125(11):2149-58
Britton JS, Edgar BA. Development. 1998 Jun; 125(11):2149-58
This seminal paper from Britton and Edgar describes how dietary nutrients (particularly amino acids) can influence both mitotic and endoreplicative cell cycles in developing larvae. In particular, they describe how a fat-derived signal is essential to stimulate neural stem cell divisions in response to dietary protein.
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