Warfarin and aspirin in patients with heart failure and sinus rhythm.
N Engl J Med. 2012 May 17; 366:1859-69
Homma S, Thompson JL, Pullicino PM, Levin B, ..., Del Valle ML, Buchsbaum R, Buchsbaum R, WARCEF Investigators. Homma S, Thompson JL, Pullicino PM, Levin B, Freudenberger RS, Teerlink JR, Ammon SE, Graham S, Sacco RL, Mann DL, Mohr JP, Massie BM, Labovitz AJ, Anker SD, Lok DJ, Ponikowski P, Estol CJ, Lip GY, Di Tullio MR, Sanford AR, Mejia V, Gabriel AP, Del Valle ML, Buchsbaum R, Buchsbaum R, WARCEF Investigators. N Engl J Med. 2012 May 17; 366:1859-69
This study compared warfarin to aspirin in patients with reduced ejection fraction and in sinus rhythm. There was no difference in outcome between the two groups. There is no compelling reason to use warfarin in this group of patients, so this should not change current clinical practice. Trial registration: NCT00041938
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