Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism.
Cell. 2012 Apr 27; 149(3):656-70
Ying H, Kimmelman AC, Lyssiotis CA, Hua S, ..., Wang YA, Chin L, Cantley LC, Depinho RA. Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik JH, Lim C, Guimaraes AR, Martin ES, Chang J, Hezel AF, Perry SR, Hu J, Gan B, Xiao Y, Asara JM, Weissleder R, Wang YA, Chin L, Cantley LC, Depinho RA. Cell. 2012 Apr 27; 149(3):656-70
One of the major consequences of tumor progression is a metabolic reprogramming to meet the requirements for continuous tumor proliferation. Although this phenomenon is clearly established, the mechanism regulating this switch remains poorly understood. In this study using an inducible KrasG12D pancreatic cancer model, Ying et al....
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