Involvement of urinary bladder connexin43 and the circadian clock in coordination of diurnal micturition rhythm.
Nat Commun. 2012; 3:809
Negoro H, Kanematsu A, Doi M, Suadicani SO, ..., Todo T, Okamura H, Tabata Y, Ogawa O. Negoro H, Kanematsu A, Doi M, Suadicani SO, Matsuo M, Imamura M, Okinami T, Nishikawa N, Oura T, Matsui S, Seo K, Tainaka M, Urabe S, Kiyokage E, Todo T, Okamura H, Tabata Y, Ogawa O. Nat Commun. 2012; 3:809
This elegant and detailed study presents fascinating new details on diurnal rhythms controlling bladder function. In addition to describing a new molecular mechanism for regulating diurnal voiding frequency in mice, it has clear implications for human voiding pathologies like enuresis (bed wetting) and nocturia (the unwelcome need to void at night)...
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