Spleen cells from young but not old immunized mice eradicate large established cancers.
Clin Cancer Res. 2012 May 1; 18(9):2526-33
Schreiber K, Arina A, Engels B, Spiotto MT, ..., Karrison TG, Weichselbaum RR, Rowley DA, Schreiber H. Schreiber K, Arina A, Engels B, Spiotto MT, Sidney J, Sette A, Karrison TG, Weichselbaum RR, Rowley DA, Schreiber H. Clin Cancer Res. 2012 May 1; 18(9):2526-33
Solid tumors arise mostly in elderly patients, but animal models usually fail to test older individuals, even though it has been known for many years that immunotherapies that are effective in young animals may fail in older ones. This study employs an animal model with many advantages over most so far described: it uses an ultraviolet...
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