Nitric oxide regulation of cyclic di-GMP synthesis and hydrolysis in Shewanella woodyi.
Biochemistry. 2012 Mar 13; 51(10):2087-99
Liu N, Xu Y, Hossain S, Huang N, Coursolle D, Gralnick JA, Boon EM. Biochemistry. 2012 Mar 13; 51(10):2087-99
This paper shows how an H-NOX (heme-nitric oxide binding) protein can control the intracellular concentration of cyclic di-guanosine monophosphate (GMP) by reciprocally regulating the di-guanylate cyclase and phosphodiesterase activities of a GGDEF-EAL protein. The NO-bound form of an H-NOX protein has previously been suggested...
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