Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases.
Sci Signal. 2010; 3(136):ra64
Moritz A, Li Y, Guo A, Villén J, ..., Cantley LC, Gygi SP, Rush J, Comb MJ. Moritz A, Li Y, Guo A, Villén J, Wang Y, MacNeill J, Kornhauser J, Sprott K, Zhou J, Possemato A, Ren JM, Hornbeck P, Cantley LC, Gygi SP, Rush J, Comb MJ. Sci Signal. 2010; 3(136):ra64
This article is interesting because it combines immunoaffinity purification with phosphomotif-specific antibodies and mass spectrometry to identify new substrates of kinases important in cancers.
The authors showed in this study a new insight into signaling pathways by comparing three different cancer cell lines and the influence...
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