[CONFERENCE POSTER]: Complex II specific dissociation links pH changes to oxidative stress for apoptosis induction.
F1000 Poster Based on: Cancer & Metabolism: Pathways to the Future. 2010
Lemarie A, Huc L, Pazarentzos E, Mahul-Mellier AL, Grimm S. F1000 Poster Based on: Cancer & Metabolism: Pathways to the Future. 2010
This poster is interesting because it suggests that complex II of the respiratory chain is a pH sensor which causes reactive oxygen species (ROS) formation during intracellular acidification induced by cytokines or anticancer drugs (see poster).
The data show...
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