Trehalose 6-phosphate phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogen Aspergillus fumigatus.
Mol Microbiol. 2010 Jun 9
Paula Sundstrom
30 Nov 2010
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Novel Drug Target
This insightful paper builds on the potential utility of trehalose metabolism as an antifungal target by demonstrating that a null mutant of Aspergillus fumigatus that lacks trehalose-6-phosphate phosphatase (T6PP) is avirulent in two murine models of aspergillosis.
The mutant had increased levels of T6PP as expected, but was not...
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