Trehalose 6-phosphate phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogen Aspergillus fumigatus.
Mol Microbiol. 2010 Jun 9
Puttikamonkul S, Willger SD, Grahl N, Perfect JR, ..., Park S, Paderu P, Perlin DS, Cramer RA. Puttikamonkul S, Willger SD, Grahl N, Perfect JR, Movahed N, Bothner B, Park S, Paderu P, Perlin DS, Cramer RA. Mol Microbiol. 2010 Jun 9
This insightful paper builds on the potential utility of trehalose metabolism as an antifungal target by demonstrating that a null mutant of Aspergillus fumigatus that lacks trehalose-6-phosphate phosphatase (T6PP) is avirulent in two murine models of aspergillosis.
The mutant had increased levels of T6PP as expected, but was not...
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