Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels.
Sci Signal. 2010; 3(145):ra77
Tian D, Jacobo SM, Billing D, Rozkalne A, ..., Hsu HH, Schlondorff J, Ramos A, Greka A. Tian D, Jacobo SM, Billing D, Rozkalne A, Gage SD, Anagnostou T, Pavenstädt H, Pavenstaedt H, Hsu HH, Schlondorff J, Ramos A, Greka A. Sci Signal. 2010; 3(145):ra77
The study demonstrates an interesting and important connection between TRPC (transient receptor potential canonical) channels, Ca2+ responses, actin remodelling and cell migration.
The authors utilized electrophysiology, Ca2+ imaging, advanced molecular biology and cell migration assays to probe the role of TRPC channels in cell...
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