Uterine epithelial estrogen receptor alpha is dispensable for proliferation but essential for complete biological and biochemical responses.
Proc Natl Acad Sci U S A. 2010 Nov 9; 107:19272-7
Winuthayanon W, Hewitt SC, Orvis GD, Behringer RR, Korach KS. Proc Natl Acad Sci U S A. 2010 Nov 9; 107:19272-7
This article is of great interest as it definitively shows that paracrine signaling is essential for uterine epithelial proliferation in the mouse. However, epithelial estrogen receptor is necessary for maintenance of viability and fertility. This is fascinating as it indicates cell type-specific requirements for the estrogen receptor...
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