Photocaged morpholino oligomers for the light-regulation of gene function in zebrafish and Xenopus embryos.
J Am Chem Soc. 2010 Nov 10; 132(44):15644-50
Scott K Silverman
28 Oct 2010
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Technical Advance
Antisense oligonucleotides have long been investigated for regulation of gene expression. In this report, the authors show that photocaged morpholino oligonucleotides are efficiently synthesized and useful for photoregulated control of gene expression in vivo, including within zebrafish embryos and Xenopus oocytes.
The photochemical...
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