Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling.
Sci Signal. 2010 Aug; 3(135):ra62
George Hasko
14 Oct 2010
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New Finding
This interesting article delineates the mechanisms of how mycobacteria induce arginase 1, thereby producing an anti-inflammatory milieu, in which mycobacteria can thrive.
The study shows that mycobacteria-infected macrophages produce interleukin (IL)-6, IL-10, and granulocyte-macrophage colony-stimulating factor (GM-CSF), which in...
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