Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling.
Sci Signal. 2010 Aug; 3(135):ra62
Qualls JE, Neale G, Smith AM, Koo MS, ..., Zhang H, Kaplan G, Watowich SS, Murray PJ. Qualls JE, Neale G, Smith AM, Koo MS, DeFreitas AA, Zhang H, Kaplan G, Watowich SS, Murray PJ. Sci Signal. 2010 Aug; 3(135):ra62
This interesting article delineates the mechanisms of how mycobacteria induce arginase 1, thereby producing an anti-inflammatory milieu, in which mycobacteria can thrive.
The study shows that mycobacteria-infected macrophages produce interleukin (IL)-6, IL-10, and granulocyte-macrophage colony-stimulating factor (GM-CSF), which in...
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