The protease inhibitor alpha-2-macroglobulin-like-1 is the p170 antigen recognized by paraneoplastic pemphigus autoantibodies in human.
PLoS ONE. 2010; 5(8):e12250
Schepens I, Jaunin F, Begre N, Läderach U, Marcus K, Hashimoto T, Favre B, Borradori L. PLoS ONE. 2010; 5(8):e12250
In the present study, Schepens et al. identify the p170 antigen targeted by paraneoplastic pemphigus (PNP) antibodies as the protease inhibitor alpha-2-macroglobulin-like-1 (A2ML1). This study gives us new insight into the pathogenesis of PNP.
PNP is a severe and often fatal autoimmune mucocutaneous blistering disease, with gastrointestinal...
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