TPL-2-mediated activation of MAPK downstream of TLR4 signaling is coupled to arginine availability.
Sci Signal. 2010 Aug; 3(135):ra61
Mieulet V, Yan L, Choisy C, Sully K, ..., Pende M, Ley SC, Moinard C, Lamb RF. Mieulet V, Yan L, Choisy C, Sully K, Procter J, Kouroumalis A, Krywawych S, Pende M, Ley SC, Moinard C, Lamb RF. Sci Signal. 2010 Aug; 3(135):ra61
This paper shows that changing arginine levels may have profound effects on the regulation of innate immunity by tumor-promoting locus (Tpl)2. Tpl2 is a mitogen-activated protein (MAP)3 kinase (MAP3K8) that is required for the activation of extracellular signal-regulated kinase (ERK) by a variety of Toll-like receptor (TLR) signals...
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