Effect of nanoparticle conjugation on gene silencing by RNA interference.
J Am Chem Soc. 2010 Jun 23; 132(24):8241-3
Robert Garbaccio
01 Sep 2010
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Confirmation, Technical Advance
The authors conducted a well-designed study to evaluate small interfering (si)RNA conjugation strategies to quantum dots. They examined the effect of labile vs. non-labile, short vs. long and passenger vs. guide strand linkage to the nanoparticle on gene silencing in vitro. The outcome clarifies a general approach that can be used...
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