Branched tricarboxylic acid metabolism in Plasmodium falciparum.
Nature. 2010 Aug 5; 466(7307):774-8
Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, Llinás M. Nature. 2010 Aug 5; 466(7307):774-8
In a tour de force of analytical biochemistry, the authors used 13C and 15N metabolic labeling, coupled with mass-spectrometry, to trace the transformations of tricarboxylic acids in malaria parasite.
They conclude that, even though the Plasmodium genome encodes all the enzymes of the "TCA cycle", these enzymes operate in two linear...
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