Autocrine purinergic receptor signaling is essential for macrophage chemotaxis.
Sci Signal. 2010; 3(132):ra55
Marcus Thelen
29 Jul 2010
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Confirmation, New Finding
This paper confirms and extends the notion that secretion and conversion of adenosine triphosphate (ATP) to adenosine diphosphate (ADP), adenosine monophosphate (AMP) and adenosine are critical for efficient directional migration of phagocytes. Genetic ablation and pharmacological inhibition indicate that several purinergic (P2Y2 and P2Y12)...
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