beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress.
Sci Signal. 2010; 3(125):ra46
Ralf Jockers and Maud Kamal
29 Jul 2010
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Confirmation, New Finding
This paper reports an example of ligand-biased signaling with respect to Beta-arrestin recruitment and ERK phosphorylation. The article is quite interesting because it shows that a mechanical physiological stimulus can induce Beta-arrestin-biased signaling identical to that found with Beta-arrestin-biased ligands. More specifica the...
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