Helicobacter pylori-derived neutrophil-activating protein increases the lifespan of monocytes and neutrophils.
Cell Microbiol. 2010 Jun; 12(6):754-64
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This interesting article describes a novel role for a Helicobacter pylori protein in modulating the inflammatory process.
The paper shows that neutrophil-activating protein (HP-NAP) is able to induce survival of monocytes, via an IL-1beta-dependent process. Monocytes exposed to HP-NAP secrete IL-1beta that can then induce survival in naive monocytes. However, it is likely that other factors may be involved, since inhibition of IL-1beta did not completely block the effect. HP-NAP was also shown to activate some anti-apoptotic proteins, particularly the anti-apoptotic protein A1, though its not clear whether this is dependent on IL-1beta. Finally, they indirectly demonstrated that HP-NAP is able to induce survival in neutrophils but only in the presence of monocytes. This interesting observation suggests that monocytes may work as intermediates in the stimulation of other innate immune response cells. Whether contaminating monocytes have mediated the reported effect on neutrophil activation in previous studies is unclear and deserves further study.
Steele-Mortimer O and Ibarra J: F1000Prime Recommendation of [Cappon A et al., Cell Microbiol 2010, 12(6):754-64]. In F1000Prime, 21 Jul 2010; DOI: 10.3410/f.4215956.4005054. F1000Prime.com/4215956#eval4005054
F1000Prime Recommendations, Dissents and Comments for [Cappon A et al., Cell Microbiol 2010, 12(6):754-64]. In F1000Prime, 26 Oct 2014; F1000Prime.com/4215956
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