Helicobacter pylori-derived neutrophil-activating protein increases the lifespan of monocytes and neutrophils.
Cell Microbiol. 2010 Jun; 12(6):754-64
This article PDF usually requires a subscription to access but you can receive the PDF, at no cost, through a special arrangement between Springer Science+Business Media and Faculty of 1000 for our Faculty Members who act as reviewers. This PDF is provided to you only for the purposes of reviewing the article while you consider preparing a recommendation of the article for F1000Prime. Other than for this purpose you warrant that you will treat the PDF as confidential. Furthermore you warrant that you will not use the PDF for any other purpose, especially but not limited to forwarding, copying, selling, distributing it whether commercially or non-commercially and that you will not make it available on any website for any other purpose.
This interesting article describes a novel role for a Helicobacter pylori protein in modulating the inflammatory process.
The paper shows that neutrophil-activating protein (HP-NAP) is able to induce survival of monocytes, via an IL-1beta-dependent process. Monocytes exposed to HP-NAP secrete IL-1beta that can then induce survival in naive monocytes. However, it is likely that other factors may be involved, since inhibition of IL-1beta did not completely block the effect. HP-NAP was also shown to activate some anti-apoptotic proteins, particularly the anti-apoptotic protein A1, though its not clear whether this is dependent on IL-1beta. Finally, they indirectly demonstrated that HP-NAP is able to induce survival in neutrophils but only in the presence of monocytes. This interesting observation suggests that monocytes may work as intermediates in the stimulation of other innate immune response cells. Whether contaminating monocytes have mediated the reported effect on neutrophil activation in previous studies is unclear and deserves further study.
Steele-Mortimer O and Ibarra J: F1000Prime Recommendation of [Cappon A et al., Cell Microbiol 2010, 12(6):754-64]. In F1000Prime, 21 Jul 2010; DOI: 10.3410/f.4215956.4005054. F1000Prime.com/4215956#eval4005054
F1000Prime Recommendations, Dissents and Comments for [Cappon A et al., Cell Microbiol 2010, 12(6):754-64]. In F1000Prime, 02 Apr 2015; F1000Prime.com/4215956
Get the most out of F1000Prime - attend a live online demonstration.
Please choose one of the following time zones:
Want to become an
has been added to your "Faculty I'm Following" page in MyF1000
Follow/Unfollow any Faculty via their recommendations, biography pages, or MyF1000
If you've forgotten your password, please enter your email address below and we'll send you instructions on how to reset your password.
The email address should be the one you originally registered with F1000.
You registered with F1000 via Google, so we cannot reset your password.
To sign in, please click here.
If you still need help with your Google account password, please click here.
You registered with F1000 via Facebook, so we cannot reset your password.
To sign in, please click here.
If you still need help with your Facebook account password, please click here.
We have sent an email to , please follow the instructions to reset your password.
If you don't receive this email, please check your spam filters and/or contact email@example.com.