Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling.
Sci Signal. 2010; 3(115):ra24
Bogeski I, Kummerow C, Al-Ansary D, Schwarz EC, ..., Bozem M, Mori Y, Hoth M, Niemeyer BA. Bogeski I, Kummerow C, Al-Ansary D, Schwarz EC, Koehler R, Kozai D, Takahashi N, Peinelt C, Griesemer D, Bozem M, Mori Y, Hoth M, Niemeyer BA. Sci Signal. 2010; 3(115):ra24
This elegant study describes redox regulation of Ca2+ signalling and investigates the physiological consequences of this regulation for functioning of T cells.
The main finding reported in this paper is the ability of hydrogen peroxide to oxidise and inhibit Ca2+ influx mediated by store-operated ORAI1 Ca2+ channels. Advanced biophysical...
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