Distinct signal codes generate dendritic cell functional plasticity.
Sci Signal. 2010; 3(105):ra4
Steve Ziegler
15 Jun 2010
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New Finding, Technical Advance
This is the first study to show that thymic stromal lymphopoietin (TSLP) activates canonical Jak/Stat and distinct nuclear factor kappaB (NF-kappaB) signalling pathways in human primary myeloid dendritic cells (mDC) in order to promote a T helper 2 response by the immune system.
Surprisingly, human TSLP promoted broad and sustained...
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