Small molecule modifiers of microRNA miR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma.
J Am Chem Soc. 2010; 132:7976-7981
Young DD, Connelly CM, Grohmann C, Deiters A. J Am Chem Soc. 2010; 132:7976-7981
This article describes an assay that is designed to discover small molecule inhibitors and activators of the transcription of the microRNA miR-122. The hepatitis C virus depends on miR-122 for replication, whilst activation of miR-122 in liver cancer cells induces apoptosis through caspase activation.
miR-122 is the most abundant...
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