Small molecule modifiers of microRNA miR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma.
J Am Chem Soc. 2010; 132:7976-7981
Nicholas Meanwell
08 Jun 2010
|
New Finding, Novel Drug Target
This article describes an assay that is designed to discover small molecule inhibitors and activators of the transcription of the microRNA miR-122. The hepatitis C virus depends on miR-122 for replication, whilst activation of miR-122 in liver cancer cells induces apoptosis through caspase activation.
miR-122 is the most abundant...
INDIVIDUAL SUBSCRIPTIONS
Get instant access to Article Recommendations from more than 5,000 expert scientists and clinical researchers, assisted by 5,000 associates, by taking out a monthly subscription. The first month of your subscription will be free of charge.
Start your personal subscription today.
Subscribe for $9.95/monthINSTITUTIONAL SUBSCRIPTIONS
Send a recommendation to your institution's librarian or information manager to request an extended free trial for all users.
Recommend to your LibrarianIf you are a librarian or information manager, you may request an extended free trial for your academic or corporate institution.
Request an Institutional Trialyour institution might be eligible for free access via our sponsorship scheme. Check our sponsorship page.
If you think you should be able to access this content, please contact us.