Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity.
Sci Signal. 2010; 3(121):ra37
Jernigan KK, Cselenyi CS, Thorne CA, Hanson AJ, ..., Hepler JR, Kozasa T, Linder ME, Lee E. Jernigan KK, Cselenyi CS, Thorne CA, Hanson AJ, Tahinci E, Hajicek N, Oldham WM, Lee LA, Hamm HE, Hepler JR, Kozasa T, Linder ME, Lee E. Sci Signal. 2010; 3(121):ra37
The signal transduction pathway activated by Wnt ligands, leading to stabilization of beta-catenin, has been studied for over 20 years. While we and others have presented considerable evidence implicating G proteins as effectors of this pathway, this has proven to be remarkably controversial (at least in some quarters), resulting...
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