Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity.
Sci Signal. 2010; 3(121):ra37
Randall Moon
04 Jun 2010
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Confirmation, Controversial, Technical Advance
The signal transduction pathway activated by Wnt ligands, leading to stabilization of beta-catenin, has been studied for over 20 years. While we and others have presented considerable evidence implicating G proteins as effectors of this pathway, this has proven to be remarkably controversial (at least in some quarters), resulting...
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