Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs.
Sci Signal. 2010; 3(109):ra12
Anuj Kumar1 and Tao Xu2
04 Jun 2010
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Technical Advance
This paper presents an impressive volume of data defining in vitro phosphorylation site motifs for yeast kinases through a clever peptide-based screening strategy. Integrating this approach with computational methods, the authors identify target-site motifs for approximately half the known kinases in yeast, providing an excellent...
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