TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy.
Sci Signal. 2010; 3(123):ra42
John Kyriakis
28 May 2010
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New Finding
This paper is important because it contributes insight into the mechanisms by which pathogen-associated molecular patterns (PAMPs), microbial products that provoke innate immune responses, trigger autophagy. PAMP-induced autophagy is central to innate immune clearance of microbes that invade the cytosol (e.g. mycoplasma). Autophagic...
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