Ammonia derived from glutaminolysis is a diffusible regulator of autophagy.
Sci Signal. 2010; 3(119):ra31
Eng CH, Yu K, Lucas J, White E, Abraham RT. Sci Signal. 2010; 3(119):ra31
This study is important because it reveals that glutaminolysis in cancer cells is accompanied by production of ammonia that acts as a diffusible inducer of autophagy.
Using an impressive suit of biochemical and cell biological approaches, the authors show that the metabolic switch of cancer cells from oxidative phosphorylation...
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