Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission.
J Biol Chem. 2009 May 15; 284(20):13843-55
Dagda RK, Cherra SJ, Kulich SM, Tandon A, Park D, Chu CT. J Biol Chem. 2009 May 15; 284(20):13843-55
This paper provides evidence for the role of PTEN-induced kinase 1 (PINK1) in the maintenance of mitochondrial homeostasis, specifically the regulation of reactive oxygen species production, mitochondrial fission/fusion and mitophagy. Moreover, the mitochondrial injury caused by the loss of PINK1 enabled the authors to propose a model...
Get instant access to Article Recommendations from more than 5,000 expert scientists and clinical researchers, assisted by 5,000 associates, by taking out a monthly subscription. The first month of your subscription will be free of charge.
Start your personal subscription today.Subscribe for $9.95/month
Send a recommendation to your institution's librarian or information manager to request an extended free trial for all users.Recommend to your Librarian
If you are a librarian or information manager, you may request an extended free trial for your academic or corporate institution.Request an Institutional Trial
your institution might be eligible for free access via our sponsorship scheme. Check our sponsorship page.
If you think you should be able to access this content, please contact us.