Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission.
J Biol Chem. 2009 May 15; 284(20):13843-55
Mark A Smith1 and Renato Santos2
13 Apr 2010
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New Finding
This paper provides evidence for the role of PTEN-induced kinase 1 (PINK1) in the maintenance of mitochondrial homeostasis, specifically the regulation of reactive oxygen species production, mitochondrial fission/fusion and mitophagy. Moreover, the mitochondrial injury caused by the loss of PINK1 enabled the authors to propose a model...
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