Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration.
Sci Signal. 2010; 3(110):ra13
John Jeremy Rice1 and Raquel Norel2
14 Jun 2011
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New Finding
The ‘Phoenix Rising’ refers to cell death inducing tissue regrowth. The paper proposed that apoptotic cells activate caspases 3 and 7 that, in turn, causes downstream stem cell proliferation and tissue regeneration. This death causing new growth is desirable in wound healing but could also have negative consequences in recurrence...
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