Increased synaptic dopamine function in associative regions of the striatum in schizophrenia.
Arch Gen Psychiatry. 2010 Mar; 67(3):231-9
Kegeles LS, Abi-Dargham A, Frankle WG, Gil R ... Hwang DR, Huang Y, Haber SN, Laruelle M Kegeles LS, Abi-Dargham A, Frankle WG, Gil R, Cooper TB, Slifstein M, Hwang DR, Huang Y, Haber SN, Laruelle M Arch Gen Psychiatry. 2010 Mar; 67(3):231-9
In contrast to influential theories, this neuroimaging study suggests that schizophrenia is not associated with dopamine dysfunction in the ventral striatum but rather in the more dorsal striatum. These data have important implications for cognitive neuroscientific theories of psychosis.
The dopamine hypothesis of schizophrenia...
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