Differences in human macrophage receptor usage, lysosomal fusion kinetics and survival between logarithmic and metacyclic Leishmania infantum chagasi promastigotes.
Cell Microbiol. 2009 Dec; 11(12):1827-41
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This manuscript demonstrates that Leishmania life cycle stages utilize different human macrophage receptors for entry, resulting in divergent intracellular fates. These results also provide an explanation for discordant reports regarding receptor utilization by Leishmania.
This study assessed the differences between how virulent metacyclic Leishmania infantam chagasi (Lic) promastigotes and avirulent Lic logarithmic promastigotes are phagocytosed by human monocyte-derived macrophages. While both stages co-localized with complement receptor 3 (CR3), only logarithmic promastigotes engaged mannose receptor (MR). Following entry, logarithmic promastigote-containing vacuoles accumulated lysosome-associated membrane protein-1 (LAMP-1) early following phagocytosis, whereas vacuoles containing metacyclic promastigotes exhibited a delay in LAMP-1 accumulation. While this study puts forth an interesting hypothesis to account for intracellular survival differences between the two life cycle stages, the role that CR3 and MR play in influencing endocytic trafficking of Leishmania parasites remains to be completely elucidated.
McDowell M: F1000Prime Recommendation of [Ueno N et al., Cell Microbiol 2009, 11(12):1827-41]. In F1000Prime, 05 Feb 2010; DOI: 10.3410/f.1797994.1327100. F1000Prime.com/1797994#eval1327100
F1000Prime Recommendations, Dissents and Comments for [Ueno N et al., Cell Microbiol 2009, 11(12):1827-41]. In F1000Prime, 27 Nov 2014; F1000Prime.com/1797994
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