Function of the nucleotide exchange activity of vav1 in T cell development and activation.
Sci Signal. 2009; 2(101):ra83
Saveliev A, Vanes L, Ksionda O, Rapley J, Smerdon SJ, Rittinger K, Tybulewicz VL. Sci Signal. 2009; 2(101):ra83
In this study, the authors try to separate out the different functions of Vav1: they look at its effect as a guanine nucleotide exchange factor (GEF) and its non-GEF functions, and also at which downstream signalling pathways are affected by each function. Significantly, this paper shows that Vav1's GEF activity is necessary for Akt...
Get instant access to Article Recommendations from more than 5,000 expert scientists and clinical researchers, assisted by 5,000 associates, by taking out a monthly subscription. The first month of your subscription will be free of charge.
Start your personal subscription today.Subscribe for $9.95/month
Send a recommendation to your institution's librarian or information manager to request an extended free trial for all users.Recommend to your Librarian
If you are a librarian or information manager, you may request an extended free trial for your academic or corporate institution.Request an Institutional Trial
your institution might be eligible for free access via our sponsorship scheme. Check our sponsorship page.
If you think you should be able to access this content, please contact us.