Function of the nucleotide exchange activity of vav1 in T cell development and activation.
Sci Signal. 2009; 2(101):ra83
Arup Chakraborty and Arvind Shankar Prabhakar
20 May 2010
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Confirmation
In this study, the authors try to separate out the different functions of Vav1: they look at its effect as a guanine nucleotide exchange factor (GEF) and its non-GEF functions, and also at which downstream signalling pathways are affected by each function. Significantly, this paper shows that Vav1's GEF activity is necessary for Akt...
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