Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution.
Nat Methods. 2010 Feb; 7(2):133-6
Andrew Singleton1 and Jose Bras2
15 Jan 2010
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Technical Advance
In this paper, Gu et al. present an optimized method for genome-scale bisulfite sequencing which has two significant advantages over the traditional methods: it requires minute amounts of starting DNA and it is shown to work well on formalin-fixed, paraffin-embedded (FFPE) samples. This approach has the potential to enable largescale...
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