Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution.
Nat Methods. 2010 Feb; 7(2):133-6
Gu H, Bock C, Mikkelsen TS, Jäger N, ..., Tomazou E, Gnirke A, Lander ES, Meissner A. Gu H, Bock C, Mikkelsen TS, Jäger N, Smith ZD, Tomazou E, Gnirke A, Lander ES, Meissner A. Nat Methods. 2010 Feb; 7(2):133-6
In this paper, Gu et al. present an optimized method for genome-scale bisulfite sequencing which has two significant advantages over the traditional methods: it requires minute amounts of starting DNA and it is shown to work well on formalin-fixed, paraffin-embedded (FFPE) samples. This approach has the potential to enable largescale...
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