Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections.
Cell. 2012 Feb 3; 148(3):434-46
Tobin DM, Roca FJ, Oh SF, McFarland R, ..., Thwaites GE, King MC, Serhan CN, Ramakrishnan L. Tobin DM, Roca FJ, Oh SF, McFarland R, Vickery TW, Ray JP, Ko DC, Zou Y, Bang ND, Chau TT, Vary JC, Hawn TR, Dunstan SJ, Farrar JJ, Thwaites GE, King MC, Serhan CN, Ramakrishnan L. Cell. 2012 Feb 3; 148(3):434-46
This paper presents an excellent example of how human genetic diversity can influence the effectiveness of treatment against an infectious disease (i.e. tuberculosis). The authors start by presenting convincing functional data generated in Mycobacterium marinum and the zebrafish model, which they then complement with human genetic...
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