Lab mice in the field: unorthodox daily activity and effects of a dysfunctional circadian clock allele.
J Biol Rhythms. 2011 Apr; 26(2):118-29
Daan S, Spoelstra K, Albrecht U, Schmutz I, ..., Poletaeva I, Dell'Omo G, Vyssotski A, Lipp HP. Daan S, Spoelstra K, Albrecht U, Schmutz I, Daan M, Daan B, Rienks F, Poletaeva I, Dell'Omo G, Vyssotski A, Lipp HP. J Biol Rhythms. 2011 Apr; 26(2):118-29
This is a remarkable study using lab mice genetically modified to have a dysfunctional Per gene (the gene coding for circadian rhythmicity) but placed in outdoor enclosures and, hence, undergoing natural and sexual selection. These studies concluded that mice underwent epigenetic compensation for an adverse genetic trait.
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