UA62784 Is a cytotoxic inhibitor of microtubules, not CENP-E.
Chem Biol. 2011 May 27; 18(5):631-41
David Stephens
26 Apr 2012
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Controversial, New Finding
This paper caught my eye as it alters our perception of the target of the small molecule inhibitor UA62784. Previously characterised as a CENP-E inhibitor, the authors here show that it is in fact a potent inhibitor of microtubule dynamics and has no inhibitory effect on CENP-E in vitro.
While clearly of interest to those in...
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