Genetic strain differences in learned fear inhibition associated with variation in neuroendocrine, autonomic, and amygdala dendritic phenotypes.
Neuropsychopharmacology. 2012 May; 37(6):1534-47
Camp MC, Macpherson KP, Lederle L, Graybeal C, ..., Lüthi A, Cryan JF, Singewald N, Holmes A. Camp MC, Macpherson KP, Lederle L, Graybeal C, Gaburro S, Debrouse LM, Ihne JL, Bravo JA, O'Connor RM, Ciocchi S, Wellman CL, Lüthi A, Cryan JF, Singewald N, Holmes A. Neuropsychopharmacology. 2012 May; 37(6):1534-47
This remarkable paper is part of a building wave of studies poised to turn research in mouse models of human behavior and psychopathology on its head. Rather than pursue the typical bottom-up approach wherein a targeted gene knockout/knockdown is mapped up onto changes in neurobiology and behavior, the work presented in this paper...
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