IFITM3 restricts the morbidity and mortality associated with influenza.
Nature. 2012 Mar 25
Everitt AR, Clare S, Pertel T, John SP, ..., Openshaw PJ, Dougan G, Brass AL, Kellam P. Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB, The GenISIS Investigators, The MOSAIC Investigators, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P. Nature. 2012 Mar 25
There has been significant debate over many years as to why some people cope with infections better than others. In particular, influenza can exert its effects in a mild form or in a much more severe way. While this reflects a range of factors including the genetics of the virus (genetic drift and, more importantly, genetic shift), the residual immunity in the population at risk and underlying co-morbidities, the role that host genetics plays is relatively under-investigated. This paper uses a knockout mouse model to show that the interferon-inducible transmembrane (IFITM)...
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