The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA.
Nucleic Acids Res. 2012 Mar 15
Reiter V, Matschkal DM, Wagner M, Globisch D, Kneuttinger AC, Müller M, Carell T. Nucleic Acids Res. 2012 Mar 15
This article reports CDK5RAP1, an inhibitor of the CDK5 kinase, as one of the rare eukaryotic radical S-adenosylmethionine (SAM) enzymes. Aberrant regulation of CDK5 leads to neurodegenerative diseases. CDK5RAP1 is shown here to be an Fe-S radical SAM enzyme, which acts as a tRNA-methylthiotransferase. An interesting finding is...
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