The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA.
Nucleic Acids Res. 2012 Mar 15
Marc Fontecave
24 Apr 2012
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New Finding
This article reports CDK5RAP1, an inhibitor of the CDK5 kinase, as one of the rare eukaryotic radical S-adenosylmethionine (SAM) enzymes. Aberrant regulation of CDK5 leads to neurodegenerative diseases. CDK5RAP1 is shown here to be an Fe-S radical SAM enzyme, which acts as a tRNA-methylthiotransferase. An interesting finding is...
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