CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage.
Nucleic Acids Res. 2012 Mar 8
David Wotton
11 Apr 2012
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New Finding
This work is interesting because it provides evidence for a function for the polycomb protein CBX4 in the DNA damage response. CBX4 is recruited to sites of DNA damage relatively early in the response, and the authors show that reducing CBX4 levels increases radiation sensitivity.
CBX4 is known to have SUMO E3 ligase activity a the...
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