Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns.
Nucleic Acids Res. 2012 Mar 1; 40(5):2345-56
Jim Maher
11 Apr 2012
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New Finding, Technical Advance
This paper propels the field of artificial control of transcription by showing that aromatic (aryl) groups appended to the turn domain of small hairpin polyamide compounds unexpectedly confers improved nuclear uptake in cultured mammalian cells. This kind of improvement offers an approach to better target delivery of this interesting...
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