Absence of sclerostin adversely affects B cell survival.
J Bone Miner Res. 2012 Mar 20
Sarah Dallas and Yasuyoshi Ueki
03 Apr 2012
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New Finding
This article is interesting and provocative because it reports novel findings that mice lacking the gene for sclerostin (Sost) show specific depletion of B cells in their bone marrow. This occurs because the Sost-null bone microenvironment cannot support normal B cell development, leading to elevated B cell apoptosis. The study...
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