Crystal structure of the µ-opioid receptor bound to a morphinan antagonist.
Nature. 2012 Mar 21
Manglik A, Kruse AC, Kobilka TS, Thian FS, ..., Pardo L, Weis WI, Kobilka BK, Granier S. Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S. Nature. 2012 Mar 21
This paper and its three companion papers in the same issue of Nature {1-6} present the high-resolution crystal structures of all four types of opioid receptors in the antagonist-bound conformations. These crystal structures are the latest G protein-coupled receptors (GPCRs) structurally determined with X-ray crystallography. They...
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