Dissecting the regulatory architecture of gene expression QTLs.
Genome Biol. 2012 Jan 31; 13(1):R7
Gaffney DJ, Veyrieras JB, Degner JF, Pique-Regi R, ..., Crawford GE, Stephens M, Gilad Y, Pritchard JK. Gaffney DJ, Veyrieras JB, Degner JF, Pique-Regi R, Pai AA, Crawford GE, Stephens M, Gilad Y, Pritchard JK. Genome Biol. 2012 Jan 31; 13(1):R7
This paper provides insights into the molecular basis of expression quantitative trait loci (eQTL), suggesting that nucleotide accessibility may bear a larger than anticipated effect on gene expression. Gaffney and colleagues observed that chromatin marks are highly enriched in eQTL, to a greater degree than that of transcription...
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