DNase I sensitivity QTLs are a major determinant of human expression variation.
Nature. 2012 Feb 16; 482(7385):390-4
Degner JF, Pai AA, Pique-Regi R, Veyrieras JB, ..., Crawford GE, Stephens M, Gilad Y, Pritchard JK. Degner JF, Pai AA, Pique-Regi R, Veyrieras JB, Gaffney DJ, Pickrell JK, De Leon S, Michelini K, Lewellen N, Crawford GE, Stephens M, Gilad Y, Pritchard JK. Nature. 2012 Feb 16; 482(7385):390-4
eQTL (expression quantitative trait loci) and especially cis eQTL are exciting because knowledge of a locus that controls an expression module leads directly to the mechanism. In contrast, identification of quantitative trait loci for disease phenotypes has usually ended up with the perplexing problem that we know that some sequence...
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