The secreted Wnt antagonist Dickkopf-1 is required for amyloid β-mediated synaptic loss.
J Neurosci. 2012 Mar 7; 32(10):3492-8
Randall Moon
17 Apr 2012
|
Confirmation, Novel Drug Target
While Wnt/beta catenin signaling has been linked to cancer for decades and there has been considerable attention and focus on the frequent mutations that activate this pathway in colorectal cancer in particular, the burgeoning evidence that Wnt/beta catenin signaling plays key roles in a range of neuropsychiatric diseases and conditions...
INDIVIDUAL SUBSCRIPTIONS
Get instant access to Article Recommendations from more than 5,000 expert scientists and clinical researchers, assisted by 5,000 associates, by taking out a monthly subscription. The first month of your subscription will be free of charge.
Start your personal subscription today.
Subscribe for $9.95/monthINSTITUTIONAL SUBSCRIPTIONS
Send a recommendation to your institution's librarian or information manager to request an extended free trial for all users.
Recommend to your LibrarianIf you are a librarian or information manager, you may request an extended free trial for your academic or corporate institution.
Request an Institutional Trialyour institution might be eligible for free access via our sponsorship scheme. Check our sponsorship page.
If you think you should be able to access this content, please contact us.