Alterations in two conserved regions of promoter sequence lead to altered rates of polymerase binding and levels of gene expression.
Nucleic Acids Res. 1980 Jun 25; 8(12):2709-23
This study is important because it helped establish that mutations in conserved upstream promoter DNA sequences affect gene expression directly. The authors demonstrated that changing the upstream DNA sequences influences levels of expression of recombinant lac promoters.
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