A distinct interaction mode revealed by the crystal structure of the kinase p38α with the MAPK binding domain of the phosphatase MKP5.
Sci Signal. 2011 Dec 20; 4(204):ra88
Zhang YY, Wu JW, Wang ZX. Sci Signal. 2011 Dec 20; 4(204):ra88
The activity of mitogen-activated protein kinases (MAPKs) is modulated by the careful coordination of kinases and phosphatases. This article provides important new structural information about the interaction between the p38a MAPK and the MAPK-binding domain of MAPK phosphatase 5 (MKP5). Not only does the structure provide new insight...
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